First off
Move ALL the unread emails into a 'Holiday Email' Folder or some such name. That way you can clear your Inbox and quickly scan and deal with all the new emails as they come in.
Once you've planned out the important things you need to get done on your first day back, set aside an hour to go through your Holiday Email folder. Do your priority task first then deal with your email.
First scan
DON'T READ OR RESPOND TO ANY EMAILS ON THIS SCAN. Just go through quickly and eliminate the spam and any email you know you don't need to read. Use the sort function to sort your email by sender or subject, which makes it easier to delete the junk. This should take only a few minutes.
Second scan
Pick out all the priority emails you need to respond to first and flag them or place them in a separate 'Action' folder.
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Set aside time to respond to your 'Action' emails - start doing this now, as you should still have plenty of time left. Go through and respond to the emails that only need a quick two-minute response.
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Leave emails requiring a longer response or more thought until later in the day when you're next planned to deal with them.
Allow yourself a few minutes to take a quick look at any new emails - in case there is anything important that needs attention, but I mean a 'few minutes'. Don't get distracted!
Third scan
If you've still got time in the hour do the third scan - if your filters haven't already sorted out Reading emails, now is the time to place all of these in the appropriate folder(s).
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Remember you don't have time to read everything, and the world won't end just because you haven't read this week's/month's newsletter.
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Now might also be the time to unsubscribe to those you never get round to reading anyway.
Fourth scan
Deal with what's left. Less urgent action emails can now be dealt with. Anything still left?